Stroke

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Striatin, a putative protein phosphatase 2A (PP2A) B-type regulatory subunit, is a multi-domain scaffolding protein that has recently been linked to several diseases including cerebral cavernous malformation which causes symptoms ranging from headaches to stroke. http://www.biomedcentral.com/1471-2091/12/54

 

Focal Cerebral Ischemia (stroke)Reduces PP2A Subunit B Expression in Brain Tissue and HT22 Cells. http://europepmc.org/articles/PMC3145983

 

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (a condition associated with seizures and strokes). http://www.mcponline.org/content/8/1/157.full

 

PP2A activation may play a significant role in cerebral lesions post-ischemia (a restriction in blood supply, a brief episode of ischemia affecting the brain is called a transient ischemic attack (TIA), often erroneously referred to as a "mini-stroke"). http://informahealthcare.com/doi/abs/10.3109/02699050903379388

 


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