Memory Loss

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There is an age-dependent change in PP2A involvement in the regulation of synaptic strength. http://www.ncbi.nlm.nih.gov/pubmed/9744962

 

Spatial memory deficit and Tau hyperphosphorylation induced by inhibiting PP2A in rat brain http://link.springer.com/article/10.1007%2FBF02832462

 

Inhibitors of PP1, PP2A and calcineurin have been shown to have deleterious effects on various forms of memory. http://www.demneuropsy.com.br/imageBank/PDF/v4n1a04.pdf

 

PP2A plays a central role in responses to chronic stresses that lead to neurodegeneration and senile dementia. http://princetoninnovation.org/magazine/2014/02/01/coffee-improves-brain-health-2/

 

Potential therapeutic effects for increased PP2A methylation in AD treatment or prevention. http://www.cumc.columbia.edu/dept/taub/res-featured-5-2014.html

 

The biochemistry of memory. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971467/

 


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