Cardiovascular Disease

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PP2A phosphatase may exert beneficial cardiovascular effects


PP2A is altered in human and experimental models of heart disease.


PP2A mediates microvascular endothelial barrier dysfunction (a hallmark for vascular diseases, a predictive of future adverse cardiovascular events).


The crucial role of PP2A in endothelial cell, (thin layer of cells that line the interior surface of blood vessels and lymphatic vessels), barrier protection.


In heart, PP2A function is necessary for normal excitation-contraction coupling, and PP2A levels are altered in heart failure.

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