The Role of PP2A A Subunits in Tumor Suppression.
PP2A has been shown to be genetically altered or
functionally inactivated in many solid cancers and
leukemia's, and is therefore a tumor suppressor.
Aberrant expression, mutations and somatic alterations of
the PP2A scaffold and regulatory subunits have been observed
in various human malignancies, including lung, breast, skin
and colon cancer, highlighting its role as a ‘tumor
Emerging studies have correlated changes in PP2A with human
diseases, especially cancer.
PP2a regulates many, if not most, aspects of cellular
activities and is a critical tumor suppressor. http://www-als.lbl.gov/index.php/contact/141-the-biological-implications-of-the-pp2a-crystal-structure.html