Alzheimer's

     < back>

Enhancing PP2A activity would decrease tau hyper-phosphorylation in Alzheimer Disease. http://www.ncbi.nlm.nih.gov/pubmed/22299660

 

Therapeutic benefits of a component of coffee in a rat model of Alzheimer's Disease. http://www.ncbi.nlm.nih.gov/pubmed/25034344

 

Among the phosphatases, which regulate the phosphorylation of tau, PP2A, the activity of which is down-regulated in Alzheimer’s Diseased brain, is by far the major enzyme. http://www.ncbi.nlm.nih.gov/pubmed/19184068

 

Downregulation of PP2A carboxyl methylation and methyltransferase may contribute to Alzheimer Disease pathogenesis.  http://www.ncbi.nlm.nih.gov/pubmed/1553513

 

Altered expression levels of the PP2A ABalphaC enzyme are associated with Alzheimer Disease pathology. http://www.ncbi.nlm.nih.gov/pubmed/15099019 

 

The down-regulation of PP2A activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's diseased brain. http://www.ncbi.nlm.nih.gov/pubmed/18586097

 

PP2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. http://www.ncbi.nlm.nih.gov/pubmed/17360897

 

PP2A: a novel druggable target for Alzheimer's disease. http://www.ncbi.nlm.nih.gov/pubmed/21644827

 

Deficiencies in phosphatase methylation play an important role in the etiology of Alzheimer's disease. http://www.ncbi.nlm.nih.gov/pubmed/19747079

 

PP2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease. http://www.ncbi.nlm.nih.gov/pubmed/11997007

 

   < back>