Striatin, a putative protein phosphatase 2A (PP2A) B-type
regulatory subunit, is a multi-domain scaffolding protein
that has recently been linked to several diseases including
cerebral cavernous malformation which causes symptoms
ranging from headaches to stroke.
Focal Cerebral Ischemia (stroke)Reduces PP2A Subunit B
Expression in Brain Tissue and HT22 Cells.
A PP2A Phosphatase High Density Interaction Network
Identifies a Novel Striatin-interacting Phosphatase and
Kinase Complex Linked to the Cerebral Cavernous Malformation
3 (a condition associated with seizures and strokes).
PP2A activation may play a significant role in cerebral
lesions post-ischemia (a restriction in blood supply, a
brief episode of ischemia affecting the brain is called a
transient ischemic attack (TIA), often erroneously referred
to as a "mini-stroke").