The findings that PP2A B subunits control distinct T-cell
function will enable corrective actions without the fear of
Dysregulation of the serine/threonine phosphatase PP2A
contributes to autoimmunity.
PP2A activity is regulated by reversible carboxyl
methylation. Demethylation is associated with inflammation.
We have identified one agent, a natural product found in
coffee, is efficacious in skin inflammation.