Overall Health

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Proper formation of PP2A holoenzymes is essential for the fitness of all eukaryotic (cells that contain a nucleus)  cells. http://www.ncbi.nlm.nih.gov/pubmed/21292165
 

Deregulation of PP2A is associated with multiple human cancers, Alzheimer’s Disease, and increased susceptibility to pathogen infection

http://www-als.lbl.gov/index.php/contact/141-the-biological-implications-of-the-pp2a-crystal-structure.html

 

A PP1–PP2A phosphatase relay controls mitotic progression (cell division). http://www.nature.com/nature/journal/v517/n7532/full/nature14019.html


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