Memory Loss

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There is an age-dependent change in PP2A involvement in the regulation of synaptic strength.


Spatial memory deficit and Tau hyperphosphorylation induced by inhibiting PP2A in rat brain


Inhibitors of PP1, PP2A and calcineurin have been shown to have deleterious effects on various forms of memory.


PP2A plays a central role in responses to chronic stresses that lead to neurodegeneration and senile dementia.


Potential therapeutic effects for increased PP2A methylation in AD treatment or prevention.


The biochemistry of memory.


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