Diabetes

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The inhibition of PP2A results in an acute worsening of insulin resistance, indicating that PP2A activity is required for insulin-stimulated glycogen storage. http://impactaging.com/papers/v5/n10/full/100611.html  

 

Emerging evidence suggests hyperactivation of PP2A in liver, muscle, retina and the pancreatic islet under the duress of glucolipotoxicity and diabetes. http://www.sciencedirect.com/science/article/pii/S0006295212003309

 

PP2A Regulation of Insulin Receptor Substrate 1 and Insulin Metabolic Signaling http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551395/ 

 

Studies of pancreatic cells indicate that impaired early insulin secretion, which is a principal risk factor for development of Type 2 diabetes in humans, could be secondary to fatty acid-mediated increases in PP2A activity. http://ajpendo.physiology.org/content/294/2/E444#ref-2

 

PP2A hyperactivity has been implicated in the pathogenesis of insulin resistance and diabetes  http://impactaging.com/papers/v5/n10/full/100611.html


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