Cardiovascular Disease

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PP2A phosphatase may exert beneficial cardiovascular effects http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551395/

 

PP2A is altered in human and experimental models of heart disease. http://www.ncbi.nlm.nih.gov/pubmed/23204520

 

PP2A mediates microvascular endothelial barrier dysfunction (a hallmark for vascular diseases, a predictive of future adverse cardiovascular events). http://cardiovascres.oxfordjournals.org/content/81/1/38?ijkey=fb7b0a87cac9a5973805083944d989c40ae6e4c2&keytype2=tf_ipsecsha

 

The crucial role of PP2A in endothelial cell, (thin layer of cells that line the interior surface of blood vessels and lymphatic vessels), barrier protection. http://www.ncbi.nlm.nih.gov/pubmed/16475161?access_num=16475161&link_type=MED&dopt=Abstract

 

In heart, PP2A function is necessary for normal excitation-contraction coupling, and PP2A levels are altered in heart failure. http://ajpheart.physiology.org/content/293/1/H109


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