Enhancing PP2A activity would decrease tau hyper-phosphorylation
in Alzheimer Disease.
Therapeutic benefits of a component of coffee in a rat model
of Alzheimer's Disease.
Among the phosphatases, which regulate the phosphorylation
of tau, PP2A, the activity of which is down-regulated in
Alzheimer’s Diseased brain, is by far the major enzyme.
Downregulation of PP2A carboxyl methylation and
methyltransferase may contribute to Alzheimer Disease
Altered expression levels of the PP2A ABalphaC enzyme are
associated with Alzheimer Disease pathology.
The down-regulation of PP2A activity is thought to play an
important role in the formation of tau hyperphosphorylation
in the Alzheimer's diseased brain.
PP2A methyltransferase links homocysteine metabolism with
tau and amyloid precursor protein regulation.
PP2A: a novel druggable target for Alzheimer's disease.
Deficiencies in phosphatase methylation play an important
role in the etiology of Alzheimer's disease.
PP2A methylation: a link between elevated plasma
homocysteine and Alzheimer's Disease.